Cristin Milioti's character

True! They are out of touch with the audience

I understood Karens as the ones who regard mask wearing as an attack on their fundamental right to ignore anything that personally inconveniences themselves - often accompanied by an irrational mistrust of science. Which sounds like Milioti's character?

Science (unbiased, non-ideological science) does not support the use of masks as a prophylactic measure against viruses. Karens are the science-denying, meddling loudmouths who ignorantly pester strangers who are not wearing masks. It is impossible to reason with a Karen because Karens are incapable of reasoning. They just know what they know, and they will attack you if they see you not going along with the program.

Has a liberal subset emerged yet which understands not wearing masks has resulted in the deaths of hundreds of thousands of people from flu over the years?

We used to laugh at those "funny" Asian people wearing their face masks in the pre covid days, yet they were SAVING LIVES! whilst the rest of us were slaughtering innocents due to our selfish non mask wearing.

Should the Government apologize and reparations be paid to the victims' families?

The "Karen" thing keeps flip flopping to whatever people want it to be as long as it can justify hating older White women deemed uncool. They can be uncool because they are too uptight about following the rules or uncool because they don't follow cool people's rules (basically opposites).

Have you noticed that the people who use it the most are White women?

They are either:
1) Really young White girls / women who just have the run of the mill dislike for older people -- Ew!
2) Relatively young White women who know that, soon, they too will be older White women -- not cool!
3) White women of the same age as Karens who are politically left and want to distinguish themselves as the "cool" White women as against uncool, politically right White women.

So, Karens can have ANY combination of 1. White (essential) 2. Female (essential) 3. older (variable) 4. Conservative. Each group of haters emphasizes the aspect most relevant to them.

Needless to say, if the hater is non-White—and remember these Karen-haters are fewer than the White ones—the part they will emphasize in their dislike is the whiteness.

Oddly, it seems far fewer men are Karen-haters, even if we might mistake they would have some misogynistic motive. They just seem to be less bother by "Karens" than other women.

TL;DR: "Karen" has proven such a versatile, shape-shifting insult because so many people can find justifications for their bias / hatred in it. It's just too EASY of an insult, and I hope it dies in 2021 -- not because there aren't some extremely annoying people out there who deserve scorn, but because it is too easy and disingenuous.