who would play annie in a remake?

I think McCarthy would do well but I also think it would be too close to what Bates was able to accomplish and would come off as falling short, she looks too similar and because of that, we the audience would just see McCarthy emulating Bates, and that never works out well in film, especially in remakes.
I think for the sake of variety, Catherine Keener would be more suited to making the character her own and could do just as well as Bates did, given the writing was competently done.

She was the first I thought of also! (McCarthy.)

CATE BLANCHETT

octavia spencer

Rosamund Pike. She looks nothing like Annie from the original but she has a cold distant look to her. I think she could pull off a lonely super fan who is psychotic

There is absolutely no reason for a remake.

McCarthy might be okay, but there's no reason the character has to be a fat chick, just because the original actress was a fat chick. Besides, there's no reason to remake the movie, anyway.

Why take a shit on this masterpiece by insulting it with a ‘remake’?