I used to work with a colleague who had Asperger's. He reminded me a bit of Sheldon. An IQ of 140 (though it's not true that all who have Asperger's are geniuses, their spread of IQ is the same as the general populace) and very good at his job; he worked a job where he could not be easily replaced, and he was the only one the company kept when they did major layoffs and shut down the whole factory in that town. He would say inappropriate and offensive things because I guess his disability made him totally clueless of the social boundaries. Very "punchable" personality... if you didn't know he was disabled and had sympathy for it, that is. He also had a squeaky-sounding voice (as when a boy's voice breaks when hitting puberty) like Sheldon can have at times, but Sheldon's isn't as extreme as his was.
The differences I see is that Sheldon doesn't take all things literally and understands sarcasm. He can proceed normal social conversations a lot better than this guy could. Sheldon doesn't seem to have difficulty maintaining eye contact and so forth. This colleague, when you were talking to him, you could clearly tell there was something 'off'. I'm not sure all people with autism are like that, though. There are traits and degrees, and I think the criteria is not as strict these days as to require all points on the scale to get a diagnosis. I know two parents who have two children each, and all four of them combined are diagnosed with it. Then I have cousins on both my parents sides and they have children who are diagnosed with ADHD and one with traits or tendency to autism. Then finally, I've been told by a psychologist that he thought I may have had Asperger's too.
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