John Candy's death led to John Hughes leaving Hollywood
I read an article a few years ago where a girl had befriended John Hughes as a penpal and he told her how upset he was that John Candy died and he blamed the studios for working him so hard. For the most part he left Hollywood and didn't come back.
"John told me about why he left Hollywood just a few years earlier. He was terrified of the impact it was having on his sons; he was scared it was going to cause them to lose perspective on what was important and what happiness meant. And he told me a sad story about how, a big reason behind his decision to give it all up was that "they" (Hollywood) had "killed" his friend, John Candy, by greedily working him too hard."