Jake Gyllenhaal to play Mysterio; Michael Keaton returning as The Vulture

The only logical thing here is to start the movie during the filming of Tony Stark's biopic starring Simon Williams. Quentin Beck does something to sabotage the movie, Pete's already hanging around set because it's about his pal Tony so Spidey's right there to come in and save the day, but Beck gets away, leading to his transformation into Mysterio.

I read that and thought similarly. The Vulture, Mysterio, and likely the Scorpion make for a nice half to a Sinister Six. Assuming they forego villains already featured in previous Sony Spider-Man films-- the Green Goblin, Dr. Octopus, the Sandman, Venom, the Lizard, the Rhino, and Electro-- who do you reckon will make up the other half of the Six?

The Prowler was hinted at in the first film, but makes for an unlikely addition, unless he's drafted in by Toomes, perhaps only to later turn to Spider-Man's side? The Shocker could be in the mix as well, leaving only one spot unfilled. Kraven is long overdue for a cinematic appearance, but he likely warrants top villain billing in a future film, so my money is on a "lesser" villain-- Hydro-Man, Cyclone, the Chameleon, or another C-Lister.