Aside from the obvious films - Salo, Cannibal Holocaust, I Spit On Your Grave, Last House On The Left, Requiem For A Dream (perferred fav.), Irreversible, Mulholland Dr (fav film of all time), and so on.
The one film that did me in was Eraserhead. I think it all depends on the person for any film. If you find the same disturbing films on each list, try browsing netflix, eventually you'll find something that will hit YOUR button.
Eraserhead is the top for me simply because it is the only film where the concept of a nightmare was actually captured and pulled off perfectly. Nothing scares you in the way a nightmare does (real life is scarier, yes, but a nightmare is just different), and even if Eraserhead doesn't scare you, you still have to accept the fact that its damn close to what a dream/nightmare is like. I find it disturbing because I really feel like I'm watching someone elses nightmare unfold before me, and I can't understand it because it is not in my mind.
And no one has mentioned Inland Empire yet (yes, i am a big fan of David Lynch)
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