New characters

Pheobe Waller-Bridge - Helena, Indy's goddaughter

Mads Mikkelson - Jurgen Voller, An ex-Nazi working with the US government and NASA and the main villain

Boyd Holbrook - Klaber, Voller's henchman and possibly government agent until his control

Shaunette Renee Wilson - Mason, government agent

Toby Jones as Basil, one of Indy's allies in flashback, possibly Helena's father

Antonio Banderas - Ally to Indy

Thomas Kretschmann - assume he's part of the WWII flashbacks

Oliver Richters - Hawk, one of Voller's henchmen

Additionally Anthony Ingruber is apparently in the movie