Did Blondell's character have herpes?
In the drunken booth scene she has a massive discolouration on her lip like she has herpes, which I assume was around then. Blondell's character was a loose girl and I thought this may have been one of the cautions they threw into the film about her lifestyle.
It looked too obvious a blemish for the cameraman, director or makeup artist to have missed and let through.