Prediction: Huge bomb
An overthought big monster movie, with stars. This'll make Ghostbusters look like a hit.
Stop to think about it. No, really, think about it. Who goes to see big monster movies? Guys! Now they're attempting to turn a big monster movie into a chick flick. And it's her neurosis that's controlling the monster. Big duhhh we already know our GF's turn into monsters at least a few days a month. We don't need to watch a movie about that! And no, chicks don't want to go watch Anne Hathaway remote control a monster, either.