You are mostly correct regarding Ashford, and mostly incorrect regarding Angie.
Let me explain:
1) About Ashford being the T-Virus' creator or not:
In RE2 we finally learn why Ashford is important when the survivors find Angie. Alice discovers Angie carries with her several shots of the Anti-Virus and their conversation goes like this:
Alice: How did you get this?
Angie: My daddy. My daddy made it for me.
He's sick. And someday, I'll get sick too. He just wanted to stop that.
When I was little I had to walk on crutches. They said I'd never get better,
just worse. He found a way to make me stronger.
Alice: The T-virus.
(We are not shown Angie nodding or otherwise responding to Alice's above statement at all because we see images of the flashback of Ashford working on his computer etc.)
Angie: Then they took the invention away from him.
Flashback: Get out of my house!
Angie: He's not a bad man. He didn't mean for any of this.
As you can see Angie
explicitly says that her father made her the Anti-Virus, and is only
implicitly agreeing with Alice about the T-virus.
If you remove that line by Alice, you can read the whole exchange as referring to the Anti-Virus. The T-Virus on its own would be useless, if Angie didn't want to turn into a zombie, so if he invented the Anti-Virus so that she can safely take the T-virus, that is still "a way to make [her] stronger".
So you can pretend that Angie wasn't sure about who the inventor of the T-Virus was, and she thought she might had been her dad, that's why she didn't correct Alice. But what she knows 100% certain, is that he made the Anti-Virus.
Also consider that Major Cain shot dead Ashford to motivate Alice to fight Nemesis. Would he had shot the creator of the T-Virus, Umbrella's most prized possession? But what if Dr. Ashford merely created the Anti-Virus? Then perhaps he is expendable.
Now, of course,
all that is nothing but fanwank. At the time RE2 came out Ashford was
absolutely intended to be the T-Virus' creator. But if ones does decide to attempt to fanwank, the above theory works not that bad actually.
2) Regarding Red Queen's connection to Angie:
In the commentary of RE2 Anderson says that in an earlier draft of the script Angie was supposed to have been the model of Red Queen, and Ashford perhaps helped build Red Queen's supercomputer. They tried for a long time to make it work, but because they needed extensive flashbacks to the original movie, and because the people in the audience that never saw it wouldn't care, they decided to
drop the idea. So in the film itself, Angie is no longer considered to be the basis of the Red Queen as she once was in earlier drafts.
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