Biggest plot hole of the entire series: White Queen's cure

I have heard that, but it doesn't really make any sense so I am ignoring it.

I mean that's obvious, but it's ok. What's not ok is that Alice never said something like "Too bad the cure didn't work." or "Too bad the White Queen got destroyed during the fight with Isaacs." or "Too bad the cure is ineffective." or.. anything.

The existence of a cure is not small news.. it's gigantic. One would think Alice would do everything in her power to make it happen; like she did in the final movie.

The way the continuity is like now, it's like after the third movie ended Alice was like "Cure, lulz, who cares, *beep* that. I like it like that. It lets me kill zombiezzzzzzzz" or "Um.... am I forgetting something that little girl told me before I fought Isaacs? Hm.. Nah.. I don't think so. Well, off to Japan it is!"

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The anti-virus was always green.

In the third film, Isaacs was working on something that could bring the zombies above their baser instincts. The zombies wouldn't be cured but they would regain enough memories back to where they could be domesticated and work as slaves.

Was the cure something they had all along? Or was it finally developed after the capture of Alice at the beginning of Retribution? Or maybe Alice had some of her clones create it while she trained the others for a year to go to Tokyo and kill Wesker.

I agree fully. The cure's shown in the other movies are not the same as this definitive airborne cure featured in TFC.

I do believe that Paul did sort this out in his head to a certain degree, because frankly he's not THAT stupid, the first few films have a proper narrative that makes sense that follows a coherent plot.

I think the problem is, he makes sense of these things in his head, but fails to make them obvious in the script.

Eg the differnces in 'the cure' between 1-6, Eg Wesker probably being a clone, Eg Ashford being a co-creator of the t-virus/creator of the anti-virus only, and so on.

A Resident Evil 7 could tie up all the horrible loose ends well enough if he made the effort.

I know all that and have agreed with you on another topic about them being different. What I'm saying is something different: Alice learns of a supposed cure in the third film and does nothing (that we are shown or told about) about it.

Which contradicts her being excited when the White Queen told her about it; it is implied by Alice's enthusiasm that she will definitely attempt to see this cure manufactured, and find out if it works, how it works, etc.

But the next movie (and the other 2 as well) says nothing about it, like it never happened.

Sure, you can pretend that in between she tried and it didn't work; or the White Queen was destroyed; or whatever; but it's a gigantic plot hole that it goes unaddressed. And when the subject of a cure comes up in RE6, their very last chance to address what happened to White Queen's cure, Alice says nothing about it. She doesn't say "That didn't work last time..." or "I've been told before about a cure" or anything. She acts again surprised, like she hears about a cure for the very first time.

tl;dr RE4 and 5 do not address what Alice did about the cure she heard about (it's okay to say "it didn't work", just SAY it), and RE6 pretends that cure never existed because Alice reacts like she has never heard about the possibility of any kind of cure.