I install a couple of mods which mean I don't need to play the story missions to get to the best stuff and locations. The story is too bad and too demotivating when I want some fun, so that's how I proceed--nuke the silly stuff.
You still have to play that first Amanaki Village mission, but thereafter what I usually do is one of two approaches:
1) Go for all the radio towers, taking out lots of bad guy patrols en route. This includes the 2nd island, as a mod makes that available from the start. Then tackle the outposts, and use the mod command to repopulate them when I capture them all--ready for my next playthru whenever, without having to go thru the whole intro bits again.
2) Try and capture all the outposts without capturing any radio towers [except maybe first, I don't remember if that must be done]. This is more difficult without the map revealed, so best if you're looking for more of a challenge.
If you're on your first playthru without mods--or using a console--then you don't have much choice. I recommend going for a few other outposts nearby first, to build your cash and weapons, and get a few bits of the skill tree opened. Focus on health skills first, craft bigger loot bags asap, and collect a bunch of the healing flora.
I usually prep my game with a dose of crafting, so I can carry a decent number of weapons and collect extra money and goods.
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