Today I caught a bit of RadioLab where they were interviewing a well-intentioned "peace pilgrim" that tried to walk across the country just as Mildred Norman had in 1953. After 3 days he failed and realized that, despite whatever was going on in his life, he was manufacturing the true torment himself by not taking a step back, identifying his issues, and taking action.
I think that reminds me of this movie because it took Pandamiglio/Birbiglia giving up his comforts and exposing himself to real failure to show him that the failures he felt in his comfortable home life were things he could change.
All in all, I really like this move as a nice slice of life. I oft prefer such "slow" or "plot-less" movies so long as they can hit a chord with me and this one did.