Absolutely Terrible (spoilers)
I sat through this movie because it sounded interesting. It's not. It's a complete mess. The cast is great, but every person in it is drastically underutilized. Why is Channing Tatum in this movie? You could have replaced him with a cardboard cutout and it would have been the exact same thing. I'm just kidding, I know why he's in it: because he's hot, and he sells movies. So really, there's no good reason for him to even be in the movie, which becomes painfully obvious as you see the writer and director struggle in vain to give him some sort of dialog and character depth. I didn't care who he was or why he was in jail or why she killed him because he was barely on the screen at all, and when he was, it was either to explain plot points in an obvious manner or to sex up the movie a bit. Tatum is a much better actor than this.
The whole antidepressant angle was extremely heavy-handed and contrived, and absolutely unbelievable. Anyone that has taken antidepressants would know that even when taking larger doses than necessary, extra serotonin in your brain is not going to turn you into a killer. The movie beats you over the head about how bad antidepressants are only to turn around and reveal that it wasn't really them after all, it was all just a scheme of some girl who had too much time on her hands (obviously the movie is meta and is really about a director with too much time on his hands).
And then some kind of securities fraud angle creeps in for no reason, and the movie is so busy cramming all these different, disjointed angles into itself that it tramples over everything that came before in the name of a lame twist that no one could possibly care about after sitting through so many minutes of bad writing. It was so bad at some points that I was actually angry. The last movie that did that to me was 'Babel'. When movies are that bad, I force myself to sit through them in their entirety, in part because I have trouble believing that a movie could be that bad, but also because it's kind of amusing to see a high-profile movie turn out so bad.
I will give it a little credit: at times, the writing did get decent and interesting enough to grab my attention back ('Babel' couldn't even manage that). But then it would always immediately go back to being bad. I also found that through most of the movie, you could ignore all dialog for 5-10 minute stretches of time without missing anything. That's a bad sign. And those brief moments of interest were completely negated by the long stretches of boredom and tedious and unnecessary dialog.
The sets were great, the cinematography was great. This film is beautiful to look at, it's just no fun to watch, and the "depth" that they struggled to create here is pretentious and shallow, and also complete bullsh**. Everyone involved in this movie would have been better off working on something else.