On Season 6B
Jeff isn't sure if Dylan O'Brien will return, it all has to do with Dylan's schedule and if he wants to return or not, but he'll definitely be in the last episode.
Theo will have a big part of the season and returns very early in the season. We'll figure out where he was during the summer and it's not a nice story, it's a sad and dark story.
Scott will find new romance.
Peter and Malia will share a lot of scenes together and we'll figure out if Malia is the reason of Peter's redemption.
There will be a time jump till 1/2 weeks before the adults are leaving for college/university.
Melissa & Chris will have a lot of awkward scenes, with and without Scott.
Many people from the past will return, Rafael McCall & Colton Haynes are 99% sure, even tho Jeff didn't say anything about Colton.
I'm not sure what more he said, only that it will be a very dark season, lots of horror and disgusting creatures but they won't move away from the humor. They'll focus a lot on Scott and he'll have a lot of questions in his mind like "can he really leave BH?".