Saw it in DC on December 10th
It was about half full at the screening I attended in DC on December 10th.
The movie reminded me of "My Sister's Keeper" in terms of genre (different plot of course as the kids aren't suing the parents in this).
Harrison Ford's acting is off in this in my opinion, as some of the scenes he was in seemed forced in how it was protrayed. However, he plays music in the lab throughout the movie that annoys everyone but I found it funny. Keri's character isn't really developed, she is just there in my opinion. Brenden is somewhat believable, and at least how his job issue gets worked out is realistic.
I did not see the trailer in advance, but I will say I am surprised it got the PG rating. There were six bad words that I counted and there is a makeout scene that you really can't see but you know it happened w/Brenden and Keri that really wasn't needed.
Wait for the rental on this.