If You Don't Get It, Don't Blame The Movie...Blame Your School System
If you don't get the movie, don't blame the movie, blame your school system for your lack of understanding. this movie is centered around 3 simple ideas which are cleanly laid out for you:
1. Apoptosis
2. MK-Ultra Project
3. The ignorance and lack of caring for civilian casualties in order to find 1 candidate
Apoptosis is when a cell basically kills itself off for the greater good of the group. This can happen when the cell is infected or damaged. Once Nick Cannon realizes he is the weak link of the group (although there is no group left), he attempts to off himself.
MK-Ultra Project was a CIA program to try and make people perfect spies, not able to be interrogated or tortured for info. it started with drug experiments, and eventually moved on to brain washing and hypnosis where the "spy" didn't even know they were a spy.
The "observer" specifically asks the "father" how a program like this can exist when MK-Ultra was shut down because of the high civilian casualty rate. He responds to her (with all this crap ass muffled whispering) "there are no lines anymore," clearing implying the ends justify the means.
so the question of why would someone do this willingly is, sorry to say, a dumb question to ask. in the final shot the "observer" asks how they can turn an apoptosis person into a willing suicide bomber, then it cuts to the final scene of "congrats, phase 1 complete." clearly through phases 2 through 4 these soon to be "martyrs" will either be brain washed, or using the MK-Ultra hypnosis techniques, be turned into unknowing suicide bombers.
and then the questions with the math of why would they sacrifice 61,459 other people in order to find one good candidate is clearly answered too. If you read about the real life MK-Ultra project you would know that apparently our loving government does not find this bad math.
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so even though this was not a total killer of a movie, please stop blaming the movie's supposed "plot holes" for your own ignorance. yes the whispering is annoying and hard to hear, but if you come into the movie with a little bit of previous brain power, there are no plot holes to blame.
Try the movie Primer if you're looking for something really mind blowing, because this movie couldn't be laid out any clearer.
"The search for truth and knowledge is often voiced loudly by those who strive for it the least"