The conventions for the post apocalyptic/last man genre require a hero/messiah fighting for a new chance for humanity. When adapting the book, I tried to think what Mary Shelley would want to see updated. Obviously, she would not want to follow any convention, she'd break them.
That's why I treated the screenplay for The Last Man as more of an anti-omega man. The "Omega Man" character could have left town for somewhere peaceful and quiet but he made a conscious decision to stay for the sake of exterminating the mutants.
Ultimately, I used as many of the interesting metaphors from Mary Shelley that still applied today, put it into an action movie format (re: Omega Man) then gave it a Mathesonesque ending (he was one of the Twilight Zone writers) and turned the genre upside-down for a different kind of post apocalyptic movie someone would want to see.
If I followed the conventions, I'd just have another low-budget, post apocalyptic genre film instead of something with a lot more story depth.
I'm working 24/7 on a few other films at the moment (for other filmmakers) so I'm glad I can come here to answer you!
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