You can, and in my opinion, you won't be missing much if you skip 5 and 6. Both of those series were crap IMO, and just recycled storylines and character types they did better in 1-4. And just when I was beginning to maybe warm up to the cast by the end of 5, they just decided to ruin it right off the bat at the beginning of 6, and yeah...just awful.
I have to warn you, though, series 7 isn't much better. It's depressing as *beep*, and it was pretty clear the writers had just completely run Skins into the ground. It's worth checking out once though because they did follow up on some classic Skins characters, but it had some major issues. 1-3 was the prime of Skins, 4 was okay, and 5-7 are the worst.
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