Improbable...
Just from watching the trailer...
Any locomotive engineer worth his/her salt would pop that train into emergency at the 1st sight of a car on the tracks, regardless of the geography(curves, grade, ect.). Granted, depending on speed and tonnage, you may or may not get stopped.
By the way, I'm an engineer. I would rather pile jackknife my train rather than hit anybody...
And on the 8th day, God squated down, took a crap, and out came the New York Yankees.