I Would've Cast
Not only can these guys act but they also bear a remarkable resemblance to the characters they'd be playing:
Aaron Eckhart as Neal Cassady
http://www.imdb.com/name/nm0001173/
Daniel Craig as Jack Kerouac
http://www.imdb.com/name/nm0185819/
David Cross as Allen Ginsberg
http://www.imdb.com/name/nm0189144/
Not sure about Ken Kesey
maybe TOM BERENGER!!!!!
Who would you have cast?