Incredible Hulk 2
This should be a rough plot of an excellent Hulk sequel. Banner traveling U.S. From NYC to LA. (Tip of hat to Hulk Tv show)
In LA Jennifer Walters, ADA LA County is prosecuting head of the Maggia Crime Family (Insert your Maggia Marvel Villain here). Jennifer Walters (played by MMA fighter chick from Fast Furious 6 by the way) gunned down on courthouse steps. In critical condition but alive.
Banner hulks out. Destroys midwest town. Thunderbolt Ross on the hunt.
Banner recovers and realized hearing his cousin Jennifer being gunned down set him off bee lines for LA to be by her side.
Being Jens cousin they both share rare blood type (AB negative is rarest n least compatable... I think)
Gives her his blood. She Hulk is born! She Hulk n Hulk destroy Maggia Crime Family.
Thunderbolt Ross n Hulkbusters show up n get WRECKED!
Hulk cutting swath through the Army bout to kill Ross. She Hulk fights Hulk because she's not a mindless beast.
Hulk escapes. Jennifer Walters makes a deal with SHIELD to cooperate.
End credits
Bonus scene Super Villain planned the Walters assassination in the hopes Banner would give her his blood. She's an easier target than her cousin.