Probably the best documentary on hereditary Schizophrenia

Schizophrenia has a strong hereditary component and it seemed to me as though Rosemary (the grandma) suffered from schizophrenia. Her behavior at the beginning of the film shows her repeating a refrain and laughing repeatedly. This mirrors the behavior of Renee some twenty odd years later with the pumpkin song. Both women at times share the same type of 'crazy' facial expressions that were probably filmed during psychotic episodes.

My guess is that Adolph & Rosemary recognized and feared that Renee had inherited the condition and submitted her for treatment. Public perception in the 1940s, when mental illness was something shameful and to be hidden, was very different by the 1960s when Psychiatry was more acceptable, with many people undergoing therapy. Electroshock therapy wasn't that uncommon and was used to treat everything from mild depression to alcoholism to more serious mental issues. I don't think that doctors (even in the 1960s & 70s) would have prescribed it without proper evaluation - certainly not on the whim of parents as implied in this film. Poor Adolph looked as though he had dealt with and tried his hardest throughout the years to maintain the appearance that everything in his household was 'normal'.

It is possible that Jonathan could have also inherited the condition. He certainly seemed to suffer from a heightened degree of narcissism and at times seemed to identify too closely with his absent mother. But it's hard to say because the film editing at times seemed very contrived and almost intentionally playing with the idea of a theatrical type of crazy.