Here is my recommended cast (Including multiple actors for any characters):

Sonic the Hedgehog:
Cartoon actor(s):Cam Clarke/Tom Kenny/Rob Paulsen/Billy West/Jeff Bennett
Live actor(s)(Voice):Shia Labeouf/Zac Efron

Dr. Ivo 'Eggman' Robotnik:
Cartoon actor(s):Jim Cummings/Pat Fraley/Mr. Lawrence/Tim Curry/Corey Burton/Clancy Brown/Tom Kane/Maurice Lamarche/Jeff Bennett/Tom Kenny/Peter Reneday/Bob Joles/John Dimaggio
Live actor(s):Paul Giamatti/Ian McKellen/John Ratzenberger/Jeffrey Tambor

Miles 'Tails' Prower
Child actor(s):Alexander Gould

Amy Rose:
Cartoon actress(es):Russi Taylor/Jennifer Hale/Jodi Benson
Live Actress(es)(Voice):Hilary Duff

Metal Sonic:
Voice:(See Sonic the Hedgehog)

Knuckles the Echidna:
Cartoon actor(s):Jim Cummings/Rob Paulsen
Live actor(s)(Voice):Matthew Broderick/Keifer Sutherland/'The Rock'/Brendan Frasier/Bruce Campbell

Vector the Crocodile:
Cartoon actor(s):Jim Cummings/Cam Clarke
Live actor(s) (Voice):Jim Carrey/Billy Crystal/Gilbert Gottfried/Jim Belushi/Ray Romano/Jason Lee/Jack Black/Patrick Warburton/Seth Rogen/Hulk Hogan

Espio the Chameleon:
Voice(s):Jon Heder

Charmy Bee:
Child Actor(s):Paulie Todd

Big the Cat:
Cartoon actor(s):Bill Fagerbakke/Jim Cummings/Pat Fraley
Live Actor(s):Brad Garrett/John Goodman/Larry the Cable Guy

Tikal the Echidna:
Voice:Brenda Song

Tikal's Father:
Voice:Nock Nolte

Shadow the Hedgehog:
Actor(s) (voice):Steve Buscemi/Robert Pattinson

Rouge the Bat:
Voice:Jennifer Tilly

Prof. Gerald Robotnik:
Actor(s):Christopher Lloyd/Peter Reneday

Maria Robotnik:
actress(es):Kristin Chenoweth/Kristin Stewart

Cream the Rabbit:
Voice(s):Emily Osment

E-123:Omega:
Voice(s):Frank Welker/Pat Fraley/Frank Oz/Paul Dooley

G.U.N. Commander:
Actors:Clancy Brown/Paul Eiding/Pat Fraley/Willem Dafoe

Black Doom:
Actors:Frank Welker/Jim Cummings/Pat Fraley/James Earl Jones

Blaze the Cat:
Voice:Penelope Cruz

Silver the Hedgehog
Voice:Noah Wyle

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here is my choices.

Sonic (voice): Shia Lebouf, johnny knoxville, ryan reynolds

Knuckles (voice): Christan Bale, Thomas Haden Church

Tails (voice): Jordan fry

Shadow (voice): Christan Bale, Robbert Pattenson

Dr. Eggman live action: Paul Giamati, Malcolm Mcdowell, Christopher Lee, Ben Kingsley,

Rouge (voice): Jennifer Tilly, Jessica Alba

Amy Rose (voice): Jessica Alba, Ashley Tisdale, Kirsten Dunst


By the way why hasn't there been a live action Sonic movie? they did with tmnt and mario.

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DOn't forget about the other characters as well as Sonic, Eggman, Tails, Amy, Knuckles, Shadow, & Rouge; as found in Knuckles' Choatix, Sonic Advetures 1 & 2, Sonic Heroes, Shadow the Hedgehog, Sonic Riders, Sonic Chronicles: Dark Brotherhood, Mario and Sonic at the Olympic Games 1 & 2, and Super Smash Bros. Brawl. Which reminds me, here are some other characters I forgot to add in as part 1:

Mighty the Armadiilo(voice): Jason Lee

Babylon Rogues(voices):Jason Earles (Jet the Hawk), Demi Lovato (Wave the Swallow), & Phill Lewis (Storm the Albatross)

Shade the Echidna (voice):Selena Gomez

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Here's part 2:

Additional suggestions for the folloeing Sonic Characters:

Sonic the Hedgehog (Voice): James McCovoy/Owen Wilson/James Marsden

Dr. Eggman: Timothy Spall/John Lithgow/Kevin Kline/Alfred Molina

Amy Rose (Voice): Amy Adams

Knuckles the Echidna (Voice): Bruce Willis/Ben Stiller/John Travolta/Jeff Bridges

Vector the Crocodile (Voice): Ernie Sabella/Will Arnett/Ken Page/Mike Myers/Ashton Kutcher/John Goodman/Michael-Leon Wooley

Shadow the Hedgehog (Voice): Johnny Depp

Rouge the Bat (Voice): Jennifer Aniston/Jennifer Love Hewitt/Jennifer Coolidge/Paris Hilton/Britney Spears/Jessica Simpson/Paulie Perrette/Idina Menzel/Katherine Heigl/Janeane Garofalo/Christina Ricci/Sandra Bullock/Sarah Michelle Gellar

Black Doom (Voice): Morgan Freeman/Geoffry Rush/Bill Nighy/Jeremy Irons/Christopher Lee

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owen wilson as sonic? no. but bruce willis as knuckels is a good choice! paul walker would be a good choice for sonic

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Here's more characters from 'Sonic & the Secret Rings' and 'Sonic & the Black Knight':

Shahra-Eva Mendes

Erazor Djinn-The Big Show

Black Knight-Ian McShane

Merlina-Susan Sarandon

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I'm surprised that no one suggested casting Tobey Maguire from the Spider-Man movies as the voice of Sonic the Hedgehog (Not that I'm saying that he would be a good voice of Sonic).

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I think Tobey would be great as Sonic! I can so picture him doing it. His voice kinda reminds me in a way the Ryan Drummond Sonic voice. He would be my top choice for Sonic. Oh yeah and Johnny Depp as Shadow he sounds just like David Humpfrey's Shadow voice it's like identicle

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Okay, you talked me into it, I even voted Maguire, Shia LaBeouf (as well), and 18 other actors for the 20 contestants to compete for the voice role of Sonic the Hedgehog on the "Idea for TV" reality TV show: Sonic Auditions at imaginecasting.com as it's own title; not only that, I also Voted Johnny Depp, along with Steve Buscemi and Robert Pattinson, and 17 other actors for a different contestant role to compete for Shadow the Hedgehog voice on that Sonic Auditions episode as well.

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johnny depp would be the perfect choice to voice shadow. his normal voice sounds like shadow

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Well, then you can vote Johnny Depp & 19 others on a 'Sonic Auditions' Page at imaginecasting.com, as well as you would give up to 20 actors for Sonic the Hedgehog, Dr. Ivo 'Eggman' Robotnik, Vector the Crocodile, & the other 17 Sonic Chracters with their own Pages.

Speaking of which, here are some additional ideas for a couple of characters if I were to add more than 20:

Vector the Crocodile: Frank Oz

Dr. Ivo 'Eggman' Robotnik: John Rhys-Davies, Dustin Hoffman, Jim Carrey, Steve Martin, David Ogden Stiers, Mark Strong, Alan Rickman, Michael Sheen, Eddie Izzard, Will Arnett, Alec Baldwin, John C. Reilly, & Rainn Wilson

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Here is my ideal voice cast.

Sonic the Hedgehog (voice): Seann William Scott

Knuckles the Echidna (voice): Idris Elba

Tails (voice): Tara Strong

Shadow (voice): Robert Downey Jr.

Dr. Eggman (voice): Jon Stewart

Amy Rose (voice): Tina Fey

Rouge (voice): Angelina Jolie

Vector the Crocodile (voice): Jim Cummings

Espio the Chameleon (voice): Eddie Izzard

Charmy Bee (voice): Kath Soucie

Big the Cat (voice): Brad Garrett

Professor Gerald Robotnik (voice): Ian McKellen

Maria Robotnik (voice): Ariana Grande

Silver The Hedgehog (voice): Leonardo DiCaprio

E-123 Omega (voice): Frank Welker

G.U.N. Commander (voice): Bruce Willis

Blaze The Cat (voice): Georgina Chapman

There will likely be other characters of cast ideas I will be adding later. When I think of them.

Update:

Jet the Hawk (voice): Rob Corddry

Wave the Swallow (voice): Mila Kunis

Storm the Albatross (voice): Thomas F. Wilson

Mighty the Armadillo (voice): Phil Daniels

Tikal the Echidna (voice): Emma Watson

Tikal's father (voice): Hugh Laurie

Shahra (voice): Reese Witherspoon

Erazor Djinn (voice): The Big Show

Merlina (voice): Helen Mirren

Black Knight (voice): Brian Blessed

Black Doom (voice): Peter Serafinowicz

Shade the Echidna (voice): Pamela Adlon

Cream the Rabbit (voice): Andrea Libman

Sir Charles Hedgehog (voice): Harrison Ford

Kid on bike "Where you going?"
Charlie Bright "Somewhere".

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