In the play, Lady Macbeth is wracked by guilt for helping her husband kill Duncan, Banquo, and Macduff' family, and starts to go insane. The biggest manifestation of her insanity is an hallucination of blood on her hand, which she obsessivly tries to clean off. She has a very famous speech that goes something like this:
"Out damn spot! Out I say! One, two. Why then 'tis time to do it. Hell is murky. Fie my lord (about Macbeth). A soldier and afeared? What need we fear who knows it, when none can call our power to account? Yet who would have thought the old man (Duncan) to have had so much blood in him? The Thane of Fife (Macduff) had a wife. Where is she now? No more my lord. You will mar all this with starting. Here's the smell of blood still. Oh, all the perfumes of Arabia will not sweeten this little hand. Look not so pale. Banquo is buried; he cannot come out on's grave." Etc.
Not too long after this, she kills herself.
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