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It certainly did not help.

Humanizing the villain and vilifying the protagonists severely hurt the film's potential.

2020's Invisible Man had a villain to be afraid and a heroin to root who was a victim of abuse.

I think he was already kind of evil prior to that. He was already quite egotistical and his pervertness didn't seem to have much to do with thier breakup. He lied about his unethical and immoral behavior behavior very early on, so he enjoyed getting away with a lot of crap that most people know isn't wise. I don't think the breakup was responsible for msking him evil, it just contributed to him being more evil.

I think you are supposed to believe the formula itself may have induced the psychosis. That's a side effect you can't determine from animals.