You know what didn't work in Saint Seiya ?
Shun, Lizard Misty and Pisces Aphrodite being male characters despite their excessive androgyny. Come on, do they really expect us to believe this is a man ? http://upload.wikimedia.org/wikipedia/en/4/4b/Hades_pisces_face.jpg
And I make a special mention to Shun's case. His character would have been much better explored if they had made him a girl because they could have made him a love interest for Hyoga.