If it comes to ambience...
This is absolutely one of the best games when it comes to ambience. The story of the game makes you feel so totally in the future, you just have to love it. The images from the movie, the (genius) music by Vangelis, it's really great.
My favorite scene in the game is the scene where you go into your apartment, into your bedroom, out on the balcony. Then you hear Blade Runner Blues playing, while McCoy stands on the balcony contemplating the mission he is on. You see the flying vehicles, the huge buildings, everything. It always gives me an Akira feeling.
Loved it!