DRUGS
First and foremost, when watching this movie I immediately thought it was all an analogy for drugs and drug use. I don't think this requires any explanation at all. The scene where Pikul pauses the game and they are laying on the bed in reality reminds me so much of moments I have experienced while using drugs, especially psychedelics. Add to that the similarities between this and Naked Lunch, another of Cronenberg's famous drug analogies, and you gain an easy insight into the deeper meaning here.
I think the videogame concept is also very relevant, and perhaps the analogy is also being made between videogames and drugs, just as we see happening with movies and EV in videodrome.
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