In one of the seediest parts of Midtown, Manhattan, strange things are going down at the aptly-named Hotel Quickie. The male patrons, who use the establishment as a playground for their every sexual whim, are mysteriously getting their genitals bitten off, with bizarre claims abounding about a carnivorous condom on the loose. Assigned to the peculiar case, Sicilian-born cop Luigi Mackeroni is initially skeptical - but the matter soon becomes intensely personal when, during an encounter at the hotel with a young rent boy, he himself is attacked by one of the man-eating prophylactics, losing a testicle in the process. It quickly transpires that the Big Apple is being besieged by an entire army of ravenous rubbers, and Mackeroni must work to crack the case before the emasculation epidemic escalates!