MJF Departure - Saddest In TV History
I can't remember feeling as sad for an actors departure from a show then when MJF left Spin City. It was such a sad moment. Obviously the reality of him having to leave beyond his control contributed to the saddness, but that episode is terrific.
Especially Mike and The Mayor saying goodbye to eachother.
The only time I was that sad to farewell a character was the sad farewell to John Ritter on 8 Simple Rules, which occured due to the sad passing of Ritter in reality. That also sticks with me.