In the episode The One with Ross's Thing....he has that skin abnormality above his butt, Phoebe tells him to see her herbal guy. I'll recap the scene
Ross undoes his pants for the guru to have a look Guru "uh huh as I suspected, it's a Kundus" Ross " what's a Kundus?" Guru " I don't know. What's a Kundus with you?"
It supposed to be a play on the phrase "What's the matter?", but in order for the joke to work, you need to have a phrase that actually sounds like "what's the matter?" (like how in The Lion King for example, the phrase is "What's a motto?"), so you're reply of "What's a (something) with you?" can sound like "What's the matter with you?"
The fact that "kundis" doesn't sound like "matter" at all may be the second joke, because it doesn't work at all. The joke is that the joke fails.