Angie is a bitch
I take it back. I didn't think she was prior to remembering this one scene and yes it was an open reference to "retardation" talking about how her bros were "retarded." Seriously, if I knew some "bro"-hating "Friends"-watching people like Paulie or Angie in real life I'd probably punch them.
But yeah.
Nevertheless kudos to Annabella Sciorra and Johnny Tuturro for bashing both those type of people.