From a Technical scientific standpoint...

How many Lbs of force would it take to twist a padlock until it breaks open like the Creature does in that early scene,just before it gets its First Victim,that Train station attendant.I'm thinking a 500-600 Lb Silverback Gorilla could probably have the actual strength to do that sort of thing,but might not have the intelligence to use its immense strength for that sort of thing,maybe it could though,what do i know,i'm no scientist just pretty good at BroScience. ; )

My generalized estimation would be likely several thousand Lbs of force,upwards of 5000 Lbs of force equalling the strength of 10 relatively strong adult men ?
Depends on the exact type of padlock obviously but i'd guesstimate roughly the strength of 10-20 relatively strong adult men brute strength wise.