I would argue that "McHale's Navy" wouldn't work because it was meant, like "Hogan's Heroes" for the WWII Generation, and acted as a coping mechanism for the Nation. You'll notice that in "McHale's Navy" they even had "lovable Japanese characters" which, considering the times was groundbreaking."Hogan's Heroes" also had fairly sympathetic, even endearing German characters, with the notable exception of the Gestapo or SS characters. People these days forget the animosity that many Americans kept against our WWII antagonists, especially the Japanese. I was born in '57, but I got "soaked" in those feelings during childhood which were expressed every weekend with the movies which were made during, and immediately following the War.
As for "2001: A Space Odyssey", it is a timeless gem for the thoughtful viewer. "Interestingly", it's true "meaning" was the idea of bioengineering the Human Race into being sentient, and raises profound questions about the Nature of God. Recently "Prometheus" seems to be delving into the bioengineering realm, but "2001" was lightyears ahead of the "herd". One other thing, there was another movie, which came out, strangely, just before "2001" (the buzz of "2001" killed it commercially) which delved into the same water. The British made/named movie was "Quatermass and the Pit", released in the US as "Five Million Years to Earth", extremely well made, thought provoking film. Check it out!