Is it me or does it look like his eyes look in two different directions?

Funny, they totally do. I'm watching him on kimmel right now and I was thinking the same thing

I did not see that at all in The Big Wedding and he had some extreme close ups in that movie.

~Krys~
My mother has me tested. I AM Kraz!:D

They definitely do! It's very prominent in In Good Company; I can't speak for anything more recent. He also has a lot of space between his lower eyelids and his irises, which can be pretty off-putting.

I just looked at some of his pictures, and you're right. I have never noticed it until right now.

Coming Soon... The December Man
http://www.youtube.com/watch?v=7qj7fRpcXRI

He clearly has a lazy eye