What is wrong with her face?
Does Emily Watson have some genetic condition? Obviously not a serious one, because she doesn't have any mental abnormalities (that I know of). But there is something very strange about her eyes and mouth and general contours and shape of her face. It doesn't look like a normal human. It looks like something has gone wrong, in a similar way to the faces of people with Down's syndrome, Williams syndrome or Angelman syndrome (but obviously she doesn't have any of those).
The first thing I saw her in was Red Dragon in which she plays a blind girl, and I actually thought she was blind (and possibly disabled in some way) because of how strange her eyes look. But it turns out that this is what she always looks like.