What USA cities would be targets in a full scale nuclear World War III

It doesn't matter. If there was a full scale nuclear war, the world would cease to exist. Simply put, no one wins in a nuclear war.

They should add whatever Canadian city Justin Bieber is living in to soften the blow a bit.

If they bombed Detroit, would anyone notice?

I’ve thought about this and it seems like the cities on the coasts would be the easiest targets. New York and LA obviously.

The ones most often destroyed or at least threatened in film. New York, Los Angeles, Chicago, San Francisco, and Washington D.C.